Glycosylations promoted by reagent triflate produce synthetic methods for the construction of scaffolding glycosidic spacious and glycoconjugates interests of biology and chemistry.

The process is expected to continue with the participation of a large number of high-energy activated intermediates such as triflates α- and β-glycosylation, or even more unstable glycosyl oxocarbenium-like species, of which only α-glycosyl triflates have been well characterized under reaction conditions representative. Interestingly, the remaining intermediates are less accessible, experimental yet described, seems to be very relevant in the α-selective process, which involves the weak acceptor.

Here, we report a detailed analysis of some paradigmatic examples and illustrations of the reaction, using a combination of chemicals, NMR, kinetic and theoretical approaches, which culminated in the unprecedented detection and quantification really β-glycosyl triflate intermediates in the mix of donor activated. This achievement is further used as a springboard for the characterization of the dynamics of triflate anomerization, which along with the substitution of the acceptor, adjust the stereochemical outcome of the reaction.

The data obtained convincingly show that, even for the reactions were very dissociative involving β-close ion pair (β-CIP) species, the formation of α-glycosides are of course preceded by a bimolecular α → β triflate interconversion, which under certain circumstances be level-step limit. Overall, our results rule out the prevalence of Curtin-Hammett rapid exchange assumption for most glycosylations and highlights the different reactivity properties of α- and β-glycosyl triflates to neutral acceptor and anion.

Click chemistry compared with thiols chemistry for the synthesis of site-selective glycoconjugate vaccine use as a carrier protein CRM 197

Conjugation chemistry is one of the main parameters affecting the immunogenicity of the vaccine glycoconjugate and rational approach towards a deeper understanding of their mechanisms of action will benefit from a very clear structure and well-marked. Here, different conjugation methods were investigated with the aim of controlling the glycosylation site and the density of the carrier protein glycosylation.

S. Typhimurium lipopolysaccharide O-antigen and the carrier protein CRM197 is used as a model. In particular, thiols and click chemistry is checked, both involving the linkage of the terminal reducing sugar units of O-antigen chain of different amino acids in the protein carrier. Thiol chemistry O-antigen conjugate is allowed only when the carrier protein is activated on the lysines and the relatively high number of linker, while the click chemistry allowed conjugate generation even when only one position on the protein activated and sites for both lysine and tyrosine.

Study Highlights click chemistry as a leading approach to the synthesis of glycoconjugates defined, useful to investigate the relationship between design conjugates and immune response. Schistosoma mansoni worms such as the release of excretion / secretory (E / S) products which modulate host immunity to allow infection. extracellular vesicles (EV) between this E / S products, yet the molecular mechanisms and function of S. mansoni EV interaction with the host immune cells is unknown.

Alpha-bungarotoxin, CF405s
00002-100ug	Biotium	100uG	EUR 193.2
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF680r
9-00003	Biotium	Ask for price Ask for price	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF680r
9-00003	Biotium	Ask for price Ask for price	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF640r
9-00004	Biotium	Ask for price Ask for price	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF640r
9-00004	Biotium	Ask for price Ask for price	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF488a
9-00005	Biotium	Ask for price Ask for price	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF488a
9-00005	Biotium	Ask for price Ask for price	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF568
9-00006	Biotium	Ask for price Ask for price	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF568
9-00006	Biotium	Ask for price Ask for price	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF594
9-00007	Biotium	Ask for price Ask for price	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF594
9-00007	Biotium	Ask for price Ask for price	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF633
9-00009	Biotium	Ask for price Ask for price	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF633
9-00009	Biotium	Ask for price Ask for price	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin
00010-1	Biotium	1MG	EUR 201.6
Description: Minimum order quantity: 1 unit of 1MG

Fluorescein-Alpha-bungarotoxin
00011	Biotium	500uG	EUR 440.4
Description: Minimum order quantity: 1 unit of 500uG

Tetramethylrhodamine-Alpha-bungarotoxin
00012	Biotium	500uG	EUR 459.6
Description: Minimum order quantity: 1 unit of 500uG

Fluorescein-alpha-bungarotoxin: (10x50ug)
00013	Biotium	10ST	EUR 500.4
Description: Minimum order quantity: 1 unit of 10ST

Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug)
00014	Biotium	10ST	EUR 559.2
Description: Minimum order quantity: 1 unit of 10ST

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug)
00015	Biotium	500uG	EUR 559.2
Description: Minimum order quantity: 1 unit of 500uG

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug)
00016	Biotium	10ST	EUR 627.6
Description: Minimum order quantity: 1 unit of 10ST

Biotin-xx-a-bungarotoxin
00017	Biotium	500uG	EUR 519.6
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate
9-00018	Biotium	Ask for price Ask for price	500uG 100ug
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate
9-00018	Biotium	Ask for price Ask for price	500uG 100ug
Description: Minimum order quantity: 1 unit of 100ug

Biotin-cAMP, diisopropylethylammonium salt:
00020	Biotium	1MG	EUR 376.8
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cAMP, diisopropylethylammonium salt: (20x50ug)
00020-1	Biotium	20ST	EUR 501.6
Description: Minimum order quantity: 1 unit of 20ST

Biotin-cGMP, diisopropylethylammonium salt:
00021	Biotium	1MG	EUR 412.8
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cGMP, diisopropylethylammonium salt: (20x50ug)
00021-1	Biotium	20ST	EUR 537.6
Description: Minimum order quantity: 1 unit of 20ST

Cyanine 644-cAMP:
00022	Biotium	1MG	EUR 589.2
Description: Minimum order quantity: 1 unit of 1MG

Cyanine 644-cAMP: (20x50ug)
00022-1	Biotium	20ST	EUR 750
Description: Minimum order quantity: 1 unit of 20ST

Fluorescein Methotrexate, triammonium salt:
00023	Biotium	1MG	EUR 337.2
Description: Minimum order quantity: 1 unit of 1MG

Staurosporine
00025	Biotium	100uG	EUR 166.8
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF543
00026	Biotium	500uG	EUR 592.8
Description: Minimum order quantity: 1 unit of 500uG

Rhodamine phalloidin 300u
00027	Biotium	300	EUR 414
Description: Minimum order quantity: 1 unit of 300

Biotin-xx-phalloidin
00028	Biotium	100U	EUR 513.6
Description: Minimum order quantity: 1 unit of 100U

Fluorescein-phalloidin
00030	Biotium	300U	EUR 414
Description: Minimum order quantity: 1 unit of 300U

Rhodamine 110 phalloidin
00032	Biotium	300ST	EUR 414
Description: Minimum order quantity: 1 unit of 300ST

Sulforhodamine 101 (Texas-Red) Phalloidin
00033	Biotium	300EU	EUR 414
Description: Minimum order quantity: 1 unit of 300EU

Phalloidin, CF405M
00034	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF405M
00034-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

CF488A-cAMP
00036	Biotium	100ug	EUR 206.4
Description: Minimum order quantity: 1 unit of 100ug

CF640R-cAMP
00037	Biotium	100ug	EUR 206.4
Description: Minimum order quantity: 1 unit of 100ug

Phalloidin, CF555
00040	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555
00040-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF647
00041	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF647
00041-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF488A
00042	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF488A
00042-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF543
00043	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF543
00043-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF568
00044	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF568
00044-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF594
00045	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF594
00045-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF633
00046	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF633
00046-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660R
00047	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660R
00047-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680R
00048	Biotium	300U	EUR 559.2
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680R
00048-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF350
00049	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF350
00049-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF640R
00050	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF640R
00050-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF532
00051	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF532
00051-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660C
00052	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660C
00052-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680
00053	Biotium	300U	EUR 559.2
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680
00053-T	Biotium	50U	EUR 176.4
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF430
00054	Biotium	300U	EUR 538.8
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF430
00054-T	Biotium	50U	EUR 166.8
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF440
00055	Biotium	300U	EUR 538.8
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF440
00055-T	Biotium	50U	EUR 166.8
Description: Minimum order quantity: 1 unit of 50U

Cholera Toxin Subunit B, CF488A conjugate
00070	Biotium	100ug	EUR 313.2
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF568 conjugate
00071	Biotium	100ug	EUR 313.2
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF594 conjugate
00072	Biotium	100ug	EUR 313.2
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF640R conjugate
00073	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF532 conjugate
00074	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF543 conjugate
00075	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF620R conjugate
00076	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF633 conjugate
00077	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF660R conjugate
00078	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF680R conjugate
00079	Biotium	100ug	EUR 338.4
Description: Minimum order quantity: 1 unit of 100ug

Human Transferrin, CF488A conjugate
00081	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF543 conjugate
00082	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF568 conjugate
00083	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF594 conjugate
00084	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF640R conjugate
00085	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF680R conjugate
00086	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF750 conjugate
00087	Biotium	1mg	EUR 186
Description: Minimum order quantity: 1 unit of 1mg

HIV-1 tat recombinant antigen
00110-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 tat recombinant antigen
00110-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 GAG P24 Recombinant Antigen
00111-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 GAG P24 Recombinant Antigen
00111-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 nef recombinant antigen
00112-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 nef recombinant antigen
00112-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 env gp41 recombinant antigen
00113-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-1 env gp41 recombinant antigen
00113-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-2 GP 36 Recombinant Antigen
00114-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa

HIV-2 GP 36 Recombinant Antigen
00114-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa

HCV core recombinant antigen
00115-V-01mg	Virogen	0,1 mg	EUR 321
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa

HCV core recombinant antigen
00115-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa

HCV core recombinant antigen, Biotin conjugate
00115-V-B-01mg	Virogen	0,1 mg	EUR 321
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate.

HCV core recombinant antigen, Biotin conjugate
00115-V-B-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate.

HCV core recombinant antigen, FITC conjugate
00115-V-F-01mg	Virogen	0,1 mg	EUR 321
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate.

HCV core recombinant antigen, FITC conjugate
00115-V-F-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate.

HCV core recombinant antigen, Rhodamine
00115-V-R-01mg	Virogen	0,1 mg	EUR 321
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate.

HCV core recombinant antigen, Rhodamine
00115-V-R-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate.

HCV NS4 recombinant antigen NS4a+b
00116-V-01mg	Virogen	0,1 mg	EUR 321
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa.

HCV NS4 recombinant antigen NS4a+b
00116-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa.

HCV NS4 recombinant antigen NS4a+b, Biotin
00116-V-B-01mg	Virogen	0,1 mg	EUR 321
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate.

HCV NS4 recombinant antigen NS4a+b, Biotin
00116-V-B-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate.

HCV NS4 recombinant antigen NS4a+b, FITC
00116-V-F-01mg	Virogen	0,1 mg	EUR 321
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate.

HCV NS4 recombinant antigen NS4a+b, FITC
00116-V-F-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate.

HCV NS4 recombinant antigen NS4a+b, Rhodamine
00116-V-R-01mg	Virogen	0,1 mg	EUR 321
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate.

HCV NS4 recombinant antigen NS4a+b, Rhodamine
00116-V-R-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate.

HCV NS3 recombinant antigen
00117-V-01mg	Virogen	0,1 mg	EUR 321
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa

HCV NS3 recombinant antigen
00117-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa

HBV core recombinant antigen
00120-V-01mg	Virogen	0,1 mg	EUR 321
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa

HBV core recombinant antigen
00120-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa

HBV core recombinant antigen, Delta
00121-V-01mg	Virogen	0,1 mg	EUR 321
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa

HBV core recombinant antigen, Delta
00121-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa

HBV surface recombinant antigen HBsAg
00122-V-01mg	Virogen	0,1 mg	EUR 321
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant

HBV surface recombinant antigen HBsAg
00122-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant

HBV surface recombinant antigen HBsAg antigen
00123-V-01mg	Virogen	0,1 mg	EUR 321
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity

HBV surface recombinant antigen HBsAg antigen
00123-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity

HBV surface recombinant antigen HBsAg antigen
00124-V-01mg	Virogen	0,1 mg	EUR 321
Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant

HBV surface recombinant antigen HBsAg antigen
00124-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant

HEV (Birma) ORF2 recombinant antigen
00131-V-01mg	Virogen	0,1 mg	EUR 321
Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659.

HEV (Birma) ORF2 recombinant antigen
00131-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659.

HEV (Birma) ORF2 recombinant antigen
00132-V-01mg	Virogen	0,1 mg	EUR 321
Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461.

HEV (Birma) ORF2 recombinant antigen
00132-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461.

AA 403-461 HEV Birma ORF2 Recombinant Antigen
00133-V-01mg	Virogen	0,1 mg	EUR 321
Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123.

AA 403-461 HEV Birma ORF2 Recombinant Antigen
00133-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123.

T, Pallidum recombinant antigen p15
00141-V-01mg	Virogen	0,1 mg	EUR 321
Description: T. Pallidum recombinant antigen p15 (full length)

T, Pallidum recombinant antigen p15
00141-V-1000ug	Virogen	1000 ug	EUR 1539
Description: T. Pallidum recombinant antigen p15 (full length)

T, Pallidum recombinant antigen p17
00142-V-01mg	Virogen	0,1 mg	EUR 321
Description: T. Pallidum recombinant antigen p17 (full length)

T, Pallidum recombinant antigen p17
00142-V-1000ug	Virogen	1000 ug	EUR 1539
Description: T. Pallidum recombinant antigen p17 (full length)

T, Pallidum recombinant antigen p45
00143-V-01mg	Virogen	0,1 mg	EUR 321
Description: T. Pallidum recombinant antigen p45 (full length)

T, Pallidum recombinant antigen p45
00143-V-1000ug	Virogen	1000 ug	EUR 1539
Description: T. Pallidum recombinant antigen p45 (full length)

T, pallidum recombinant antigen TmpA
00144-V-01mg	Virogen	0,1 mg	EUR 321
Description: T. Pallidum recombinant antigen TmpA (full length)

T, pallidum recombinant antigen TmpA
00144-V-1000ug	Virogen	1000 ug	EUR 1539
Description: T. Pallidum recombinant antigen TmpA (full length)

HCV core 2-119aa recombinant antigen
00150-V-01mg	Virogen	0,1 mg	EUR 321
Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a

HCV core 2-119aa recombinant antigen
00150-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a

HCV Core 24 Antigen
00151-V-01mg	Virogen	0,1 mg	EUR 321
Description: HCV core 24 antigen.

HCV Core 24 Antigen
00151-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV core 24 antigen.

HCV core recombinant antigen
00152-V-01mg	Virogen	0,1 mg	EUR 321
Description: HCV core recombinant antigen a.a.105-302

HCV core recombinant antigen
00152-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV core recombinant antigen a.a.105-302

HCV NS3 1192-1456 aa Recombinant Antigen
00153-V-01mg	Virogen	0,1 mg	EUR 321
Description: HCV NS3 1192-1456aa recombinant antigen a.a.1192-1459. Available genotypes: 1a, 1b, 2b, 2c, 5, 6a

HCV NS3 1192-1456 aa Recombinant Antigen
00153-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV NS3 1192-1456aa recombinant antigen a.a.1192-1459. Available genotypes: 1a, 1b, 2b, 2c, 5, 6a

HCV NS3 1359-1456aa antigen
00154-V-01mg	Virogen	0,1 mg	EUR 321
Description: HCV NS3 1359-1456aa antigen. The protein contains immunodominant regions (1359-1456aa). available genotypes: 1a, 1b, 2b, 3, 4, 5, 6

HCV NS3 1359-1456aa antigen
00154-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV NS3 1359-1456aa antigen. The protein contains immunodominant regions (1359-1456aa). available genotypes: 1a, 1b, 2b, 3, 4, 5, 6

HCV NS4 mosaic recombinant antigen
00155-V-01mg	Virogen	0,1 mg	EUR 321
Description: HCV NS4 mosaic recombinant antigen a.a1691-1710, 1712-1733, 1921-1940. Genotypes available: 1, 2, 3, 5.

HCV NS4 mosaic recombinant antigen
00155-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV NS4 mosaic recombinant antigen a.a1691-1710, 1712-1733, 1921-1940. Genotypes available: 1, 2, 3, 5.

HCV NS4 1916-1947aa recombinant antigen
00156-V-01mg	Virogen	0,1 mg	EUR 321
Description: HCV NS4 1916-1947aa recombinant antigen.

HCV NS4 1916-1947aa recombinant antigen
00156-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV NS4 1916-1947aa recombinant antigen.

HCV NS5 2061-2302aa recombinant antigen
00157-V-01mg	Virogen	0,1 mg	EUR 321
Description: HCV NS5 2061-2302aa recombinant antigen.

HCV NS5 2061-2302aa recombinant antigen
00157-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV NS5 2061-2302aa recombinant antigen.

HCV NS5 2212-2313aa recombinant antigen
00158-V-01mg	Virogen	0,1 mg	EUR 321
Description: HCV NS5 2212-2313aa recombinant antigen. Available genotypes: 1a, 1b, 2a, 2b, 3a, 3b, 4, 5, 6a.

HCV NS5 2212-2313aa recombinant antigen
00158-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV NS5 2212-2313aa recombinant antigen. Available genotypes: 1a, 1b, 2a, 2b, 3a, 3b, 4, 5, 6a.

HAV VP1-P2A recombinant antigen
00159-V-01mg	Virogen	0,1 mg	EUR 321
Description: HAV VP1-P2A recombinant antigen a.a. 722-830.

HAV VP1-P2A recombinant antigen
00159-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HAV VP1-P2A recombinant antigen a.a. 722-830.

HAV VP4-VP2 recombinant antigen
00160-V-01mg	Virogen	0,1 mg	EUR 321
Description: HAV VP4-VP2 recombinant antigen a.a. 55-164.

HAV VP4-VP2 recombinant antigen
00160-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HAV VP4-VP2 recombinant antigen a.a. 55-164.

HAV P2C-P3A recombinant antigen
00161-V-01mg	Virogen	0,1 mg	EUR 321
Description: HAV P2C-P3A recombinant antigen a.a. 1492-1606.

HAV P2C-P3A recombinant antigen
00161-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HAV P2C-P3A recombinant antigen a.a. 1492-1606.

HAV P3C recombinant antigen
00162-V-01mg	Virogen	0,1 mg	EUR 321
Description: HAV P3C recombinant antigen a.a. 1643-1743.

HAV P3C recombinant antigen
00162-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HAV P3C recombinant antigen a.a. 1643-1743.

HAV VP3 recombinant antigen
00163-V-01mg	Virogen	0,1 mg	EUR 321
Description: HAV VP3 recombinant antigen a.a. 304-415.

HAV VP3 recombinant antigen
00163-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HAV VP3 recombinant antigen a.a. 304-415.

HAV VP1-P2A recombinant antigen
00164-V-01mg	Virogen	0,1 mg	EUR 321
Description: HAV VP1-P2A recombinant antigen a.a. 669-782.

HAV VP1-P2A recombinant antigen
00164-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HAV VP1-P2A recombinant antigen a.a. 669-782.

HAV HAV P2C recombinant antigen
00165-V-01mg	Virogen	0,1 mg	EUR 321
Description: HAV HAV P2C recombinant antigen a.a. 1121-1234.

HAV HAV P2C recombinant antigen
00165-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HAV HAV P2C recombinant antigen a.a. 1121-1234.

HAV P2C-P3A recombinant antigen
00166-V-01mg	Virogen	0,1 mg	EUR 321
Description: HAV P2C-P3A recombinant antigen a.a. 1392-1521.

HAV P2C-P3A recombinant antigen
00166-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HAV P2C-P3A recombinant antigen a.a. 1392-1521.

Here we show that EVs are released by S. mansoni schistosomula internalized by monocyte-derived human dendritic cells (moDCs). Importantly, we show that the uptake is mainly mediated by DC-SIGN (CD209). Blocking DC-SIGN is almost completely canceled EV uptake, while blocking the mannose receptor (MR, CD206) or dendritic cell immunoreceptor (DCIR, CLEC4A) had no effect on EV uptake.