N-glycomic profiling of colorectal cancer according to tumor stage and location

Changes in the glycosylation seen in various types of cancer, including colorectal cancer (CRC). Glycans, the sugar moieties of glycoconjugates, is involved in many important functions relevant to cancer and can be of value as a biomarker.

In this study, we have used mass spectrometry to analyze the N-glycan profile of 35 CRC tissue samples and 10 samples of healthy tissue from patients with non-CRC undergoing surgery for other reasons. Tumor samples were divided into groups depending on the location of the tumor (intestinal right or left) and phase (II or III), while samples of healthy intestine is divided into the right or left.

The level of N-glycan composition and class of neutral and acidic glycans are analyzed in a total of ten different groups. Surprisingly, no significant difference in the level of glycan when all right-and left-sided CRC samples are compared, and some differences (such as the H3N5 abundance neutral N-glycan) visible when the sample is divided by both location and stage. Some significant differences were found in the levels of glycans and glycan class when the phase II and III samples were compared, and these glycans can be of value as a potential new marker of cancer progression.

In order to validate our findings, we analyzed samples of healthy tissue of the colon right and left and did not find a significant difference in the level of one of the glycans are analyzed, confirming that our findings when comparing samples of CRC from the right and left colon was not due to normal variation glycans level between right and left intestines healthy. In addition, the levels of glycans H4N3F1P1 acid, H5N4F1P1, and S1H5N4F1 found changes in certain cancers but gut the location-specific manner, suggesting that the CRC affects the level of glycan in the same way regardless of the location of the tumor.

 N-glycomic profiling of colorectal cancer according to tumor stage and location
N-glycomic profiling of colorectal cancer according to tumor stage and location

Sialylation and bioactivity Protein Reduces Serum Amyloid P antifibrotic in Sera of Patients with Idiopathic Pulmonary Fibrosis

Pulmonary fibrosis is a chronic and usually fatal disorder characterized by the progressive formation of scar tissue such as in the lungs. silicic acid is often found as a terminal sugar on glycoconjugates such extracellular protein glycosylations. Sialidases, also known as neuraminidases, glycoconjugates desialylate. Serum amyloid P (SAP), a serum pentameric glycoprotein which has two sialic acids in each polypeptide, inhibits the differentiation of monocytes into fibrocytes and promote human PBMC to accumulate high levels of extracellular IL-10.

When SAP desialylated with sialidase, the effect of SAP on fibrocyte differentiation and IL-10 were severely hampered accumulation. Interestingly, in patients with pulmonary fibrosis, no increased level of sialidase activity in bronchoalveolar lavage fluid, increased levels of sialidases in the lungs, and decreased levels of SAP in the sera. To elucidate the role of SAP desialylation in pulmonary fibrosis (IPF) the pathogenesis of idiopathic, we purified serum SAP from IPF patients and healthy controls and gauge the extent of sialylation and bioactivity of purified SAP.

D-Galactose (D-Gal) (BSA)
20-abx281009
  • EUR 523.00
  • EUR 244.00
  • EUR 1497.00
  • EUR 606.00
  • EUR 384.00
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Bovine Serum Albumin Biotinylated (Biotin-BSA)
BTN-BSA 5 mg
EUR 286.00
Ibrutinib drug-Bovine Serum Albumin (BSA) Conjugate
IBT15-BSA 100 ug
EUR 529.00
Dinitrophenyl (DNP)-BSA protein Conjugate
AV-9330-BSA 10 mg
EUR 286.00
Glycated Bovine Serum Albumin (BSA) with ?-Galactose
SPR-203A 0.05 mg
EUR 310.00
Description: Untagged synthetic panspecies Galactose BSA Glycoconjugate for WB, ELISA. The biological activity of this protein has not yet been tested.
Glycated Bovine Serum Albumin (BSA) with ?-Galactose
SPR-203B 2x0.05 mg
EUR 457.00
Description: Untagged synthetic panspecies Galactose BSA Glycoconjugate for WB, ELISA. The biological activity of this protein has not yet been tested.
Glycated Bovine Serum Albumin (BSA) with ?-Galactose
SPR-203C 4x0.05 mg
EUR 653.00
Description: Untagged synthetic panspecies Galactose BSA Glycoconjugate for WB, ELISA. The biological activity of this protein has not yet been tested.
mPEG-BSA (Molecular Weight: 5,000-linear)
PEG-BSA-05K 100 ug
EUR 286.00
mPEG-BSA (Molecular Weight: 10,000-linear)
PEG-BSA-10K 100 ug
EUR 286.00
mPEG-BSA (Molecular Weight: 20,000-linear)
PEG-BSA-20K 100 ug
EUR 286.00
mPEG-BSA (Molecular Weight: 40,000-linear)
PEG-BSA-40K 100 ug
EUR 286.00
(DRAAGQPAG)3 peptide (repeat-sequence peptide of the P. vivax circumsporozoite protein, CSP) conjugated with BSA
DRAA31-BSA 0.5 mg
EUR 529.00
(PPPPNAND)3 peptide (repeat-sequence peptide of the P. berghei circumsporozoite protein, CSP) conjugated with BSA
PPPP321-BSA 0.5 mg
EUR 529.00
(NVDP)4 peptide (minor repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) conjugated with BSA
NVDP41-BSA 0.5 mg
EUR 529.00
(NANP)5 peptide (25-aa, repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) conjugated with BSA
NANP51-BSA 0.5 mg
EUR 529.00
Bovine Serum Albumin (BSA) ELISA Kit
DLR-BSA-Ge-48T 48T
EUR 387.00
  • Should the Bovine Serum Albumin (BSA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Bovine Serum Albumin (BSA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Bovine Serum Albumin (BSA) ELISA Kit
DLR-BSA-Ge-96T 96T
EUR 494.00
  • Should the Bovine Serum Albumin (BSA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Bovine Serum Albumin (BSA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Bovine serum albumin (BSA) removal kit (Antibody based aff matrix; sufficient to remove 1-2 mg BSA from Bioprocessed material), 2 ml aff column
800-302-BSA 1 Kit
EUR 347.00
Bovine serum albumin (BSA) removal kit (Antibody based aff matrix; sufficient to remove 10-20 mg BSA from Bioprocessed material), 10 ml aff column
800-310-BSA 1 Kit
EUR 895.00
Bovine serum albumin (BSA) removal kit (Antibody based aff matrix; sufficient to remove 25-50 mg BSA from Bioprocessed material), 25 ml aff column
800-325-BSA 1 Kit
EUR 1450.00
General Bovine Serum Albumin (BSA) ELISA Kit
RDR-BSA-Ge-48Tests 48 Tests
EUR 551.00
General Bovine Serum Albumin (BSA) ELISA Kit
RDR-BSA-Ge-96Tests 96 Tests
EUR 766.00
General Bovine Serum Albumin (BSA) ELISA Kit
RD-BSA-Ge-48Tests 48 Tests
EUR 527.00
General Bovine Serum Albumin (BSA) ELISA Kit
RD-BSA-Ge-96Tests 96 Tests
EUR 732.00
Vaccigel Alum adjuvant adsorbed with Bovine Serum Albumin (BSA @1 mg/ml), Vaccine adjuvant
AV-1010-BSA 1 ml
EUR 286.00
Pre-diluted BSA (bovine serum albumin) standards (1 set) for BCA Optima Protein Assay kit
BCA-BSA-1 1 pk
EUR 164.00
D-(+)-Galactose
abx082116-25g 25 g
EUR 189.00
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D-(+)-Galactose
abx082291-25g 25 g
EUR 203.00
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D-(+)-Galactose
abx082441-25g 25 g
EUR 189.00
  • Shipped within 5-10 working days.
D-Galactose
HY-N0210 10mM/1mL
EUR 126.00
D-Galactose
GAL15-N 10 g
EUR 286.00
D-(+)-Galactose
GB0215 25g
EUR 56.96
  • Product category: Biochemicals/Carbohydrates/Sugars
L-(-)-Galactose
GC5727-100MG 100 mg
EUR 110.00
L-(-)-Galactose
GC5727-250MG 250 mg
EUR 205.00
L-(-)-Galactose
GC5727-25MG 25 mg
EUR 54.00
L-(-)-Galactose
GC5727-500MG 500 mg
EUR 341.00
D-(+)-Galactose
GC7360-100G 100 g
EUR 54.00
D-(+)-Galactose
GC7360-1KG 1 kg
EUR 150.00
D-(+)-Galactose
GC7360-250G 250 g
EUR 70.00
D-(+)-Galactose
GC7360-500G 500 g
EUR 94.00
D-(+)-Galactose
GC7360-5KG 5 kg
EUR 469.00
D-Galactose
TBW01610 100mg Ask for price
Pre-diluted BSA (bovine serum albumin) standards (750 ug/ml) for BCA Optima Protein Assay kit
BCA-BSA-750 1 ml
EUR 225.00
BSA and BGG Stock standards (1 vial each @ 2 mg/ml) for BCA Optima Protein Assay kit
BSA-BGG-1 1 pk
EUR 286.00
BSA-galactose coated plates for lectin testing by ELISA, 5 plates/pk
GAL16-CP 1 Pk
EUR 408.00
Pre-diluted BSA (bovine serum albumin) standards (250, 125, 62.5, 31.25, and 0.0 ug/ml) for BCA Optima Protein Assay kit
BCA-BSA-2 1 pk
EUR 164.00
Galactose Assay Kit
55R-1459 100 assays
EUR 740.00
Description: Assay Kit for detection of Galactose in the research laboratory
Galactose Assay Kit
55R-1463 100 assays
EUR 706.00
Description: Assay Kit for detection of Galactose in the research laboratory
Galactose Kinase antibody
70R-49778 100 ul
EUR 244.00
Description: Purified Polyclonal Galactose Kinase antibody
Galactose Kinase Antibody
20-abx009234
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
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Galactose Mutarotase (Recombinant)
20-abx073309
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
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DSPE-PEG-Galactose
abx085184-2kDa1g 2 kDa; 1 g
EUR 1191.00
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DSPE-PEG-Galactose
abx085184-34kDa1g 3.4 kDa; 1 g
EUR 1191.00
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DSPE-PEG-Galactose
abx085184-5kDa1g 5 kDa; 1 g
EUR 1191.00
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NH2-PEG-Galactose
abx085244-2kDa1g 2 kDa; 1 g
EUR 565.00
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NH2-PEG-Galactose
abx085244-34kDa1g 3.4 kDa; 1 g
EUR 565.00
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NH2-PEG-Galactose
abx085244-5kDa1g 5 kDa; 1 g
EUR 565.00
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Galactose Standard, 90UL
C146-90UL 90UL
EUR 123.00
Galactose Oxidase, 1EA
C147-1EA 1EA
EUR 123.00
Galactose 1-phosphate
HY-113143 10mg
EUR 108.00
Human Galactose-Deficient IgA1(Galactose-Deficient IgA1) ELISA Kit
EH4013 96T
EUR 524.10
  • Detection range: 14.06-900 ng/ml
Description: Method of detection: Indirect ELISA;Reacts with: Homo sapiens;Sensitivity: 8 ng/ml
Albumin (Human, Mouse, rat, bovine and others) removal kit (synthetic dye based matrix; sufficient to remove 20-40 mg BSA from Bioprocessed material), 2 ml aff column
800-200-BSA 1 kit
EUR 286.00
Albumin (Human, Mouse, rat, bovine and others) removal kit (synthetic dye based matrix; sufficient to remove 50-100 mg BSA from Bioprocessed material), 5 ml aff column
800-205-BSA 1 kit
EUR 773.00
Albumin (Human, Mouse, rat, bovine and others) removal kit (synthetic dye based matrix; sufficient to remove 250-500 mg BSA from Bioprocessed material), 25 ml aff column
800-225-BSA 1 kit
EUR 2425.00
Recombinant Human Galactose Mutarotase
7-02794 5µg Ask for price
Recombinant Human Galactose Mutarotase
7-02795 20µg Ask for price
Recombinant Human Galactose Mutarotase
7-02796 1mg Ask for price
Acetobromo-Alpha-D-Galactose
abx188579-1kg 1 kg
EUR 2388.00
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Galactose Kinase Blocking Peptide
20-abx062653
  • EUR 272.00
  • EUR 411.00
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PCL(5K)-PEG-Galactose
abx085406-2kDa1g 2 kDa; 1 g
EUR 570.00
  • Shipped within 5-10 working days.
EnzyChrom Galactose Assay Kit
EGAL-100 100
EUR 416.00
Description: Quantitative determination of galactose by colorimetric (570nm) or fluorimetric (530nm/590nm) methods. Procedure: 20 min. Kit size: 100 tests. Detection limit: 10 µM. Shelf life: 3 months. Shipping: on ice; storage: -20°C.
NH2-PEG-Galactose,10K
HE005072-10K-1g 1g
EUR 359.00
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.
NH2-PEG-Galactose,2K
HE005072-2K-1g 1g
EUR 359.00
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.
NH2-PEG-Galactose,3.4K
HE005072-3.4K-1g 1g
EUR 359.00
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.
NH2-PEG-Galactose,5K
HE005072-5K-1g 1g
EUR 359.00
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.
2-Deoxy-D-galactose
GC5572-10G 10 g
EUR 341.00
2-Deoxy-D-galactose
GC5572-1G 1 g
EUR 86.00
2-Deoxy-D-galactose
GC5572-2G 2 g
EUR 126.00
2-Deoxy-D-galactose
GC5572-5G 5 g
EUR 221.00
DSPE-PEG-Galactose,10K
LP096072-10K-1g 1g
EUR 852.00
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.
DSPE-PEG-Galactose,2K
LP096072-2K-1g 1g
EUR 852.00
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.
DSPE-PEG-Galactose,3.4K
LP096072-3.4K-1g 1g
EUR 852.00
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.
DSPE-PEG-Galactose,5K
LP096072-5K-1g 1g
EUR 852.00
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.
Human Galactose ELISA Kit
QY-E05637 96T
EUR 361.00
BSA
31C-CH0114 50 mg
EUR 133.00
Description: Bovine Serum Albumin for use in the research laboratory
BSA Control for AGE-BSA
35R-AA007 10 mg
EUR 224.00
Description: BSA Control for AGE protein (BSA modified), Cat No. 30R-AA007
Testosterone 3 BSA Protein (BSA)
abx060856-1mg 1 mg
EUR 578.00
  • Shipped within 5-10 working days.
Ibrutinib drug-Human Serum Albumin Conjugate
IBT16-BSA 100 ug
EUR 529.00
D-Galactose (D-Gal) Antibody
20-abx178973
  • EUR 1177.00
  • EUR 578.00
  • 0
  • 1
  • Please enquire.
Galactose-1-Phosphate Uridylyltransferase (Recombinant)
20-abx073963
  • EUR 1609.00
  • EUR 328.00
  • EUR 230.00
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  • 2
  • Shipped within 5-10 working days.
PCL(5K)-PEG-Galactose, 2K
HE116072-2K-G G
EUR 359.00
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.
Galactose 1-phosphate Potassium salt
HY-113143A 50mg
EUR 165.00
Galactose Colorimetric/Fluorometric Assay Kit
K621-100
EUR 512.00
Galactose Colorimetric/Fluorometric Assay Kit
K2126-100 100 assays
EUR 502.00
Native Dactylium dendroides Galactose Oxidase
NATE-0273 150 u
EUR 270.00
Histamine [G-BSA] (G-G-BSA)
DAG3327 1mg
EUR 1234.00
Cyclic citrullinated peptide-BSA(CCP-BSA)
E64I00802 100ug
EUR 343.00
AGE-BSA
2221-10
EUR 370.00
AGE-BSA
2221-50 Ask for price
BSA antibody
20R-1871 100 ug
EUR 673.00
Description: Rabbit polyclonal BSA antibody
BSA antibody
20R-AR042 20 mg
EUR 327.00
Description: Rabbit polyclonal BSA antibody
BSA antibody
70R-12462 100 ug
EUR 460.00
Description: Rabbit polyclonal BSA antibody
BSA antibody
70-BC67 1 mg
EUR 191.00
Description: Affinity purified Chicken polyclonal BSA antibody
BSA antibody
70C-CR1016GAP 1 mg
EUR 430.00
Description: Affinity purified Goat polyclonal BSA antibody
LSD-BSA
65R-1007 1 mg
EUR 743.00
Description: LSD-BSA Conjugated Hapten
BSA Antibody
48061-100ul 100ul
EUR 333.00
BSA Antibody
48061-50ul 50ul
EUR 239.00
BSA Antibody
35643-100ul 100ul
EUR 252.00
BSA antibody
10R-1795 100 ul
EUR 435.00
Description: Mouse monoclonal BSA antibody
BSA antibody
10R-10573 100 ul
EUR 349.00
Description: Mouse monoclonal BSA antibody
BSA antibody
10-1911 200 ul
EUR 543.00
Description: Mouse monoclonal BSA antibody
BSA antibody
10R-A139B 500 µg
EUR 771.00
Description: Mouse monoclonal BSA antibody
BSA Antibody
5998-100
EUR 354.00
BSA Antibody
5998-30T
EUR 146.00
BSA Antibody
1-CSB-PA000390
  • EUR 222.00
  • EUR 195.00
  • 0
  • 1
  • Form: Liquid
  • Buffer: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. Affinity purification
Description: A polyclonal antibody against BSA. Recognizes BSA from Cow. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:2000-5000
Paromomycin [BSA]
DAG-P2529 1mg
EUR 780.00
Ciclosporin [BSA]
DAG-WZ017A 1 mg
EUR 1040.00
Acetaminophen [BSA]
DAG2957 0.5mg
EUR 780.00
Chloramphenicol [BSA]
DAG2974 1mg
EUR 584.00
Gentamycin [BSA]
DAG2993 1mg
EUR 715.00
PCP [BSA]
DAG3015 1 mg
EUR 715.00
estosterone [BSA]
DAG3023 1mg
EUR 910.00
Digoxin [BSA]
DAG3043 0.5ml
EUR 715.00
Methamphetamine [BSA]
DAG3101 1mg
EUR 897.00
Secobarbital [BSA]
DAG3102 1 mg
EUR 780.00
Oxazepam [BSA]
DAG3106 1 mg
EUR 897.00
Carisoprodol [BSA]
DAG3107 1 mg
EUR 780.00
Biotin [BSA]
DAG3197 1mg
EUR 481.00
Acrolein [BSA]
DAG3266 100ug
EUR 1040.00
Agmatine [BSA]
DAG3267 100ug
EUR 845.00
Carnosine [BSA]
DAG3279 1mg
EUR 1105.00
Diclofenac [BSA]
DAG3299 1mg
EUR 1105.00
Dopamine [BSA]
DAG3302 1mg
EUR 1105.00
Adrenaline [BSA]
DAG3306 1mg
EUR 1364.00
Glycine [BSA]
DAG3313 250ug
EUR 715.00
Glyoxal [BSA]
DAG3314 250ug
EUR 780.00
Ibuprofen [BSA]
DAG3353 1mg
EUR 1221.00
Malondialdehyde [BSA]
DAG3366 1mg
EUR 1170.00
Naproxen [BSA]
DAG3370 250ug
EUR 585.00
Nicotinamide [BSA]
DAG3371 1mg
EUR 845.00
Pyridoxal [BSA]
DAG3394 1mg
EUR 1235.00
Pyridoxine [BSA]
DAG3395 1mg
EUR 1235.00
Riboflavin [BSA]
DAG3399 1mg
EUR 845.00
Rotenone [BSA]
DAG3400 mg
EUR 780.00
Buprenorphine [BSA]
DAG394 1mg
EUR 780.00
Propoxyphene [BSA]
DAG397 1 mg
EUR 1105.00
Fentanyl [BSA]
DAG398 1 mg
EUR 697.00
Tramadol [BSA]
DAG399 1mg
EUR 1222.00
Ketamine [BSA]
DAG400 1mg
EUR 715.00
Cotinine [BSA]
DAG401 1mg
EUR 780.00
THC [BSA]
DAG406 1mg
EUR 715.00
Phenobarbital [BSA]
DAG421 1mg
EUR 845.00
Theophylline [BSA]
DAG426 10mg
EUR 780.00
Amoxicillin [BSA]
DAG4461 0.5mg
EUR 780.00
Ampicillin [BSA]
DAG4462 0.5mg
EUR 780.00
Apramycin [BSA]
DAG4463 0.5mg
EUR 780.00
Bacitracin [BSA]
DAG4464 1mg
EUR 780.00
Cloxacillin [BSA]
DAG4467 0.5mg
EUR 780.00
Neomycin [BSA]
DAG4470 0.5ml
EUR 780.00
Streptomycin [BSA]
DAG4472 0.5ml
EUR 780.00
Melamine [BSA]
DAG4476 1mg
EUR 780.00
Ractopamine [BSA]
DAGA-001B 1mg
EUR 715.00
Salbutamol [BSA]
DAGA-002B 1mg
EUR 780.00
Clenbuterol [BSA]
DAGA-003B 1mg
EUR 780.00
Pb2+ [BSA]
DAGA-005B 1mg
EUR 1105.00
Cd2+ [BSA]
DAGA-006B 1mg
EUR 897.00
Hg2+ [BSA]
DAGA-007B 1mg
EUR 897.00
Cu2+ [BSA]
DAGA-008B 1mg
EUR 780.00
Ochratoxin [BSA]
DAGA-012B 1mg
EUR 780.00
Fumonisin [BSA]
DAGA-014B 1mg
EUR 780.00
Deoxynivalenol [BSA]
DAGA-016B 1mg
EUR 715.00
Sterigmatocystin [BSA]
DAGA-017B 1mg
EUR 845.00
Methyltestosterone [BSA]
DAGA-020B 1mg
EUR 780.00
Medroxyprogesterone [BSA]
DAGA-021B 1mg
EUR 780.00
Diethylstilbestrol [BSA]
DAGA-022B 1mg
EUR 714.00

We found that some IPF patients have abnormally high levels of NEU3 sialidase in their sera and that the SAP in the sera of patients with IPF have abnormally high levels of abnormally low desialylation and the ability to inhibit fibrocyte differentiation and induces accumulation of extracellular IL-10 by PBMCs. These results indicate that SAP desialylation may play a role in the pathogenesis of IPF and which inhibits NEU3 could be a potential therapeutic target for IPF.